Celebrex relates to NSAIDs. Preparation has analgesic, anti-inflammatory, antipyretic effects. It is destroying substances in the body that cause inflammation, pain and fever (fever). In experiments with animals remedy showed efficacy in reducing the incidence of colon cancer. When applying this medication frequency of formation of gastroduodenal ulcers and complications associated therewith, is considerably lower than with other NSAIDs, such as acetylsalicylic acid, naproxen, ibuprofen, which is confirmed by the results of endoscopic examinations. The difference in the development of ulcers is statistically significant. The medicament is well absorbed from the gastrointestinal tract, reaching a maximum concentration of 2-3 hours. Before you order Celebrex online overnight no rx you should consult a specialist.
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Remedy is prescribed for patient’s symptomatic treatment of:
- ankylosing spondylitis;
- rheumatoid arthritis;
- back pain;
- musculoskeletal, and other types of post-operative pain;
- primary dysmenorrhea.
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Contraindications may include:
- asthma, urticaria, or allergic reactions after aspirin taking;
- status after coronary artery bypass surgery;
- peptic ulcer in acute phase;
- gastrointestinal bleeding;
- inflammatory bowel disease;
- heart failure;
- peripheral artery disease and also cerebrovascular disease, severe;
- severe hepatic impairment;
- renal failure, severe (no experience of application);
- lactation (breastfeeding);
- the age of 18 years;
- hypersensitiveness to the drug;
- hypersensitivity to sulfonamides.
Celebrex indications and contraindications
Every human can make the order and to buy Celebrex without prescription. With careful use patients take it with diseases of the gastrointestinal tract (stomach ulcer, a bleeding disorder), fluid retention and edema, hepatic dysfunction moderate disorders of the cardiovascular system, cerebrovascular diseases, dyslipidemia, diabetes mellitus, peripheral arterial disease, severe somatic diseases. Do not use the medication in children, as there is no evidence of its safety of use in children.
Ways of applying and dosages
The widely distributed form of packing Celebrex 100 mg 90 pills is bought by many ill people. Patient is recommended the intake preparation 200 mg twice daily. The complications of the cardiovascular system are dependent on the dose, the drug should be used in the lowest effective dosage, courses of short duration. Application for osteoarthritis recommended daily dosage is 200 mg once by day. If necessary, the dosing may be increased to 800 mg per day without increasing the adverse effects' risk. For rheumatoid arthritis patients apply 200 - 400 mg a day, in 2 divided doses. For ankylosing spondylitis patients are advised 200 mg for day. When applying medicine for patients with moderate reduction in liver function, reduction of daily recommended dosage is 2 times. Experience in the use of the remedy in people with severe hepatic impairment is not noted. In renal insufficiency, mild to moderate severity, reduction in dose is not required.
Celebrex collateral effects and special directions
For not prolonged application (up to 12 weeks) in doses of 100-800 mg adverse reactions include:
- allergic reactions (itching, rash);
- peripheral edema;
- urinary tract infection;
- flu-like reaction;
- blurred vision;
- angioneurotic edema;
- heart failure;
Before ordering Celebrex online you should consult with your doctor and get acquainted with remedy’s annotation more detail. Preparation may increase the risk of thrombosis, including the vital organs (heart and brain), and therefore, possibly, treatment should be carried out in a minimally effective dose over a short period of time. Medicament does not replace aspirin, as it has antiplatelet properties, so it is impractical to cancel. Gastric ulcers and duodenal ulcers are more common in older patients, in patients with peptic ulcers in history, in debilitated patients, while taking acetylsalicylic acid. Blood pressure should be strictly monitored during the course of treatment, as the drug may contribute to the development of hypertension. The medicine may have a nephrotoxic effect, so during the course of therapy, careful monitoring of renal function is necessary.
There can be received unpleasant reactions after concurrent using of medications:
- as a result of the simultaneous application with warfarin it may increase the risk of bleeding, until the fatal;
- for the concomitant administration of fluconazole and ketoconazole, the concentration of remedy in the blood may rise twice;
- in the appointment of ACE inhibitors or angiotensin 2 NSAID may diminish the antihypertensive effect of them;
- together with lithium, the level of lithium in the blood increases about 17%, so this combination requires careful monitoring and analysis of the patient;
- purpose of this medicament and other NSAIDs is impermissible.
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