Erythromycin and its pharmacological actions
Erythromycin refers to the antibiotic’s range. For the spectrum of antimicrobial action this preparation is closed to penicillins. The medication is active against different gram positive or possible gram negative bacteria (pneumococci, staphylococci, gonococci, streptococci, meningococci and so on). There can be also a number of gram-positive bacterias, rickettsia, Brucella, agents of trachoma (an infectious eye disease that can lead to blindness) and syphilis. The preparation practically or weakly doesn’t operate to the majority of gram-negative bacteria, small or medium viruses, fungi and micro bacteria. Erythromycin is tolerated better than peniiilliny, and can be taken if you are allergic to penicillin. In therapeutic dosages remedy acts bacteriostatic (prevents bacterial growth). Antibiotic resistance generally develops rapidly, and with other macrolide antibiotics there is noted a cross-resistance. The combined using of tetracyclines, streptomycin and sulfonamides observe increase in activity of medication. Today people can order Erythromycin online overnight no rx in any convenient time.
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Medicine is generally applied under treating of:
- sore throat;
- otitis media;
- infections of the genitourinary system (including gonorrhea);
- infections of the gastrointestinal tract (including caused by Campylobacter jejuni);
- bacteriocarrier in diphtheria;
- acne and different others.
Order Erythromycin online
You may buy Erythromycin online pharmacy. The drug is also indicated for the prevention of infection (endocarditis) in dental interventions in patients with valvular heart disease and patients with the presence of hypersensitivity to penicillin in the case of indications for its use. Before you begin your treatment with this medical agent it is necessary to give a consultation with medical specialist. The contraindications include:
- hypersensitiveness to macrolide antibiotics or any other substance included in the preparation,
- simultaneous reception of terfenadine or astemizole,
- significant hearing loss.
To apply with caution in humans with impaired liver function, arrhythmia (in history), lengthening the interval QT, jaundice (in history), hepatic or renal insufficiency, in the period of lactation. If you are planning to buy Erythromycin without prescription please have a consultation with a doctor for remedies application.
Ways of applying and dosages
Patients usually order the most distributed pack of Erythromycin 250 mg 90 pills. For adults dosage is 1-2 tablets four times a day (every six hours). In the case of severe infections and chronic dose may be increased, however, not recommended for more than 2g of medicine per day. Babies take an average of 30-40mg per 1 kg of body weight by day, divided into 2-4 reception. For patients with renal insufficiency, and also for older people do not require special dosing. Patients with hepatic impairment should be reduced dosage of the drug. The duration of treatment typically is from 7 to 10 days, but depending on the situation at the discretion of the treatment can be increased. Preparation is take for 1 hour before a meal or within 2 hours after ingestion. Tablets drink plenty of fluids.
Erythromycin collateral effects and special directions
Collateral effects of treatment with medicine are relatively rare:
- digestive system: tenesmus, vomiting, epigastric pain, nausea, cholestatic jaundice, diarrhea, goiter, abnormal liver function, pseudomembranous enterocolitis, pancreatitis, elevated liver transaminases;
- effects caused by chemotherapeutic action: oral or vaginal candidiasis;
- the senses: hearing loss, tinnitus (with high dosages - more than 4 g/day);
- allergic reactions: urticaria, or eosinophilia, skin rash, anaphylactic shock;
- cardio-vascular system: tachycardia, flickering and / or atrial flutter;
- local reactions: phlebitis and several others.
Before people can make the ordering Erythromycin online you need to know about the probability of developing ototoxic effect was higher in patients with renal and hepatic impairment and also in elderly patients.
For the simultaneous using with other preparations there can be also unpleasant results such as:
- medication increases the concentration of cyclosporine in blood plasma, and also may increase the nephrotoxicity risk;
- drugs that generally block tubular secretion, lengthens T1 / 2 of medication;
- medicine is incompatible with clindamycin, lincomycin, chloramphenicol (antagonism);
- medicament reduces the beta-lactam antibiotics bactericidal action (cephalosporins, penicillins, and carbapenems);
- with simultaneous applying of erythromycin the content of theophylline increases;
- concomitantly with drugs metabolized in the liver may increase the drug's concentration of in plasma;
- intravenous introduction of remedy increases the effects of ethanol;
- medication reduces the clearance of midazolam and triazolam and thus may enhance the pharmacological effects of benzodiazepines;
- when concomitantly with terfenadine, astemizole the arrhythmias can be developed (ventricular flutter and flicker, ventricular tachycardia, or death);
- simultaneous application slows the elimination of methylprednisolone, felodipine and coumarin anticoagulants;
- Erythromycin may also increase the bioavailability of digoxin;
- preparation reduces the effectiveness of hormonal contraception.
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