Xanax and its pharmacological actions
Xanax relates to anti anxiety preparations (tranquilizers). Preparation enhances the inhibitory effects of endogenous GABA in the CNS by the increasing of GABA-receptor mediator sensitivity; reduces the excitability of the subcortical structures of the brain, inhibits the polysynaptic spinal reflex. Order Xanax online overnight no rx. Pronounced anxiolytic activity (as reducing of emotional stress, anxiety, fear) is generally combined with moderate somnific effect; shortens the sleep period, increases the sleeping duration, and usually reduces the quantity of nighttime awakenings. The mechanism of sleeping tablets action is the oppression of the cells' reticulated formation of brain stem.
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Patients are appointed the remedy under:
- anxiety, neuroses, accompanied by danger, anxiety, stress, sleep disturbance, irritability, and also somatic disorders;
- somatic depressions;
- neurotic reactive depressions, accompanied by loss of interest in things, loss of sleep, loss of appetite, depressed mood;
- mixed anxiety and depression;
- anxiety depression that developed on the background of somatic illnesses;
- panic disorders in combination phobia and without symptoms.
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Contraindications for medicine’s intake are:
- myasthenia gravis;
- narcotic analgesics;
- acute alcohol poisoning;
- hypnotics and psychoactive medications;
- severe COPD;
- acute respiratory failure;
- depressions (severe).
It may be easy to buy Xanax without prescription today. In the treatment of patients with this medicament the use of ethanol is strictly prohibited. The efficacy and safety of the medication in patients younger than 18 years has not been established. With endogenous depression it may be applied together with antidepressants. In applying in patients with depression there were cases of hypomania and mania. With the sudden discontinuation of Xanax there can be observed syndrome "cancel" (irritability, depression, or insomnia, sweating and others.), especially with a long reception more than 8-12 weeks. If patients have the unusual reactions, as acute state of excitement, increased aggressiveness, anxiety, hallucinations, suicidal thoughts, increased muscle cramps, shallow sleep, treatment should be discontinued.
Ways of applying and dosages
Nowadays most of ill people choose Xanax 2mg 180 pills. People take the medicine inside, 2-3 times a day. The dose is adjusted depending on the severity of the syndrome, individual human's sensitivity and his reaction to the medicine. You start with minimal amount 0,25-0,5 mg per day with a consequent increase in the 1st evening. Elderly patients are appointed 0,25mg. A further increase in dosing 0,5-0,75mg is carried out with care with good tolerability. The duration of the appointment is from a few days up to 3 months. When panic disorders it is indicated 0,5mg three times a day, the daily dosing can reach 3-6mg. Because of the possible medicine dependence preparation’s longer continuous using is not recommended. If it is necessary, the therapy discontinuation gradually reduces the dose by 0,5mg every three days.
Xanax collateral effects and special directions
Medicine’s adverse reactions include:
- the nervous system: drowsiness, ataxia, dizziness, fatigue, decreased ability to concentrate, disorientation, headache, mental retardation and motor response, unsteady gait, euphoria, tremors, depression, memory loss, confusion, impaired coordination of movements, weakness, dystonic extrapyramidal reactions, depressed mood, myasthenia gravis, dysarthria; aggressive outbursts, confusion, agitation, anxiety, muscle spasms, suicidal tendencies, hallucinations, irritability, agitation, insomnia.
- digestive system: heartburn, diarrhea, dry mouth or salivation, nausea, abnormal liver function, loss of appetite, jaundice;
- hematopoiesis: neutropenia, leukopenia, agranulocytosis, anemia, thrombocytopenia;
- genitourinary system: urinary retention, decreased or increased libido, renal dysfunction, urinary incontinence, dysmenorrhea;
- allergic reactions;
- effect on the fetus: CNS depression;
- other: addiction, remedy dependency, decrease in blood pressure, rarely weight loss, blurred vision, tachycardia.
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There can be various results for the simultaneous applying with other medications as:
- mutual enhancement effect notes, with the appointment of antipsychotic, antiepileptic medicines or hypnotics, and narcotic analgesics, central muscle relaxants;
- simultaneous treating with digoxin increases the risk of cardiac glycoside intoxication;
- microsomal oxidation inhibitors in liver enzymes increase and decrease the concentration of inductors in plasma;
- preparation increases the concentration in plasma of imipramine;
- fluvoxamine increases medicine concentration in plasma and side effects risk;
- with simultaneous use of fluoxetine the concentration of medicament in plasma may increase due to the reduction of metabolism, clearance under fluoxetine influence, that is accompanied by psychomotor impairment.
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