Zoloft and its pharmacological actions
Zoloft relates to antidepressants’ group. Sertraline is the active component of the medicament. It stops reuptake of serotonin, which commit to allocate its neurons. As a result, the concentration of the neurotransmitter in the synaptic cleft rises and addresses the underlying causes of depression - serotonin deficiency. Significant correction mental state of patients with depression is caused by effect on serotonin receptors. It manifests itself in improving mood, elimination of phobias, anxiety, reducing feelings of anguish, loss of appetite. The preparation acts on 5-HT receptors. On norepinephrine reuptake, dopamine affects weakly. There is no sedative, cardiotoxic effect or anticholinergic action and effect of stimulation. Medicine does not cause the formation of dependence. Prolonged therapy can lead to reduced activity of adrenaline receptors in the brain. Patients are recommended to have doctor’s consultation before you order Zoloft online overnight no rx in any time you want to purchase this medical agent.
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Medication is indicated for the treating of the following disorders:
- preventing of major depressive episodes recurrence;
- major depression episode;
- social anxiety disorders;
- panic disorder;
- OCD in adults and children aged 6-17 years;
Order Zoloft online
People need to buy Zoloft online pharmacy in order to save the time. Preparation is not prescribed for:
- hypersensibility to the active substance;
- use of sertraline with MAO inhibitors irreversible actions is contraindicated because of serotonin syndrome (SS) risk with symptoms such as tremor agitation, and hyperthermia. To begin therapy with sertraline is impossible for at least 14 days after MAO inhibitor irreversible action discontinuation;
- Concomitant using of drug and pimozide.
Take with care if you have neurological disorders (including mental retardation), mania, epilepsy, liver and / or renal failure, weight loss, in childhood. It’s better to ask a doctor about medicine indications if you are going to buy Zoloft without prescription. Anxiety, insomnia, panic attacks, hostility, irritability, aggressiveness, psychomotor restlessness, impulsivity, hypomania, or mania are noted in adults and children taking the antidepressants. These symptoms may precede the emergence of suicidality. Patient should consider changing the therapeutic regimen, or withdrawal of the drug if manifestations of depression are steadily deteriorating, suicidality or symptoms of increasing severity of suicidality appear.
Ways of applying and dosages
Generally many patients choose the package Zoloft 25 mg 180 pills. Medicament is prescribed 1 time / day in the morning or evening. Tablets can be taken regardless of mealtime. For depression and OCD therapy is generally initiated with a dosage 50 mg by day. For PTSD, panic disorder, social phobia patients begin with 25 mg per day, which increased after 1 week to 50 mg. Use of the remedy under the scheme may reduce the incidence of early adverse effects of panic disorder characteristic treating. Some effect can be observed 7 days after beginning cure, but the overall effect is usually achieved after 2-4 weeks (or even for a longer time in OCD). During the long-term maintenance therapy medication is administered in a minimum effective dosage, which is subsequently varied depending on the clinical effect. If it is decided to discontinue therapy, medication should be withdrawn gradually as quickly as possible, but it should be remembered that the abrupt discontinuation of treatment may be accompanied by withdrawal symptoms. Before treatment it is necessary to make examination to determine the patient's risk of developing bipolar disorder. Remedy is not intended for the treating of bipolar depression.
Zoloft collateral effects and special directions
The usage of tablets may be accompanied by:
- allergic reactions;
- bleeding (including nose);
- dry mouth;
- increased appetite (possibly as a result of elimination of depression);
- unstable stool;
- stomach cramps or abdominal pain;
- bloating or pain;
- weight loss;
- movement disorders (extrapyramidal symptoms, changes in gait);
- symptoms of depression;
- skin flushing or "tides" of blood to the face;
- visual disturbances (including blurred vision);
- sexual dysfunction;
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- use of medicine with MAO inhibitors with irreversible actions, such as selegiline is contra-indicated;
- the antibiotic linezolid should not be used in patients taking sertraline;
- concurrent using of medicament and pimozide is impossible due to the narrow therapeutic range of pimozide;
- the simultaneous use of sertraline 200 mg on day are not potentiated the effects of alcohol, haloperidol, carbamazepine, phenytoin on cognitive and also psychomotor functions in healthy study participants, but the simultaneous using of preparation with alcohol is not recommended;
- usage with a lithium-containing drugs causes increased tremor of limbs, with remedies of the depressing effect on the central nervous system - increased depression.
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